Institution:
Leibniz Institute for Plasma Science and Technology (INP) e.V. and Rostock University Medical Center
Location:
Greifswald, Germany
Research Focus:
Oxidation-Driven Processes in Human Keratinocytes
DC1 – Zengyu Wang
Zengyu’s project investigates how biomolecules, such as proteins and lipids, change in response to plasma treatments for actinic keratosis. By using advanced mass spectrometry, Zengyu aims to uncover the biochemical mechanisms that underpin plasma medicine’s effects, providing critical insights for future therapeutic applications.
Key Techniques: Mass spectrometry
Expected Impact: Through her research, Zengyu hopes to deepen understanding of plasma medicine’s role in actinic keratosis, advancing both the technology and its potential for targeted skin disease treatments.
Motivation: „Plasma technology is a novel and low-cost strategy for the treatment of skin diseases, which motivates me to explore the area and push the edge of plasma medicine further“
Fun Fact: Zengyu has a passion for film photography and dreams of curating her own gallery at home in the coming years.
Collaborations: Zengyu collaborates closely with Lauren (INP), Agnieszka (UMR), and Aminur (UAntwerp) for biological validations, and partners with Miltenyi Biotec for insights into translating scientific findings to clinical applications.
Career Aspirations: Zengyu aims to build a career in analytical chemistry, especially within mass spectrometry and its applications in medicine, in an interdisciplinary setting.
„Being part of the PlasmACT network has been an incredibly good experience, deepening my passion for plasma research and its potential in medical treatments.“
Institution:
Leibniz Institute for Plasma Science and Technology (INP) e.V. and Rostock University Medical Center
Location:
Greifswald, Germany
Research Focus:
Cell Biology and Inflammation in Plasma-Treated Diseased Keratinocytes
DC2 – Lauren McKeever
Lauren’s research aims to assess the impact of gas plasma on the viability and metabolism of actinic keratosis (AK) cells, investigate the cellular mechanisms behind gas plasma-induced cell death, and evaluate the immune response triggered by plasma treatment. Through her work, she seeks to develop a deeper understanding of how plasma can be harnessed for non-invasive treatments.
Key Techniques: Flow cytometry, advanced microscopy, and molecular biology assays.
Expected Impact: Lauren’s research could lead to new, non-invasive treatment options for actinic keratosis. By revealing the cellular mechanisms involved in gas plasma’s effects, her findings may contribute valuable insights into the broader potential of plasma in skin cancer prevention.
Motivation: „I’ve always been fascinated by molecular biology and how tiny changes at the cellular level can have profound effects on health. The prospect of using gas plasma technology to selectively target diseased cells sparked my interest and drives my passion for exploring innovative, non-invasive treatment options.“
Fun Fact: Lauren is dedicated to making science accessible to everyone and enjoys sharing the exciting advancements in treating skin conditions on social media by running the PlasmACT social pages (https://linktr.ee/plasmact) (https://lnkd.in/eBZcPtKZ)
Collaborations: Lauren collaborates with CEVA SANTE ANIMALE in a non-academic partnership and the University of Antwerp for academic partnerships, bridging the gap between cutting-edge research and real-world applications.
Career Aspirations: Lauren aspires to continue her research in academia or industry, focusing on cross-industry collaborations that drive innovation in medical technologies.
„Being part of the PlasmACT network has been an incredible journey so far that fuels my passion for plasma research and scientific outreach. This collaborative environment inspires me every day to push the boundaries of what’s possible in biomedical research.“
Institution:
GREMI Laboratory, Centre National de la Recherche Scientifique (CNRS), Université d’Orléans
Location:
Orléans, France
Research Focus:
Multijet cold plasma for medical applications: physical and electrical characterization, optimization and safety assessment
DC3 – Pradeep Murugesan
Pradeep’s research aims to assess the electrical and physical characterizations of plasma multi-jets and collaborate with other Doctoral Candidates (DCs) to optimize the multi-jet prototype in alignment with EU medical device regulations. His research aims to design and develop a pre-market version of the multi-jet technology, specifically targeting the treatment of actinic keratosis.
Key Techniques: electrical characterizations of two- and four-jet setups, measurement of current, voltage, and energy for relevant targets, optical emission spectroscopy
Expected Impact: Pradeep’s research could contribute to advancements in plasma medicine by optimizing plasma multi-jet technology for therapeutic applications in treating actinic keratosis. By conducting detailed electrical and physical characterizations of plasma jets, he aims to enhance their efficacy and safety profiles.
Motivation: „Beginning with a master’s thesis at UGent and progressing to a role as a design engineer, I’ve gained extensive knowledge in plasma technology, particularly its biomedical applications. I’m motivated by the opportunity to translate scientific research into market-ready products that comply with European regulations.“
Fun Fact: Pradeep lives in his „own parallel universe, full of funny thoughts and wild imaginations“. He’s „secretly turning them into a story, and one day, [he’ll] turn it into a novel—a magical world that’s healthy and lively!“ Pradeep also enjoys philosophical talks, no matter how long they take!
Collaborations: Pradeep is involved in two secondments: one at the University of Antwerp, focusing on gathering spatio-temporal data on plasma species, and another at MPG, where he will develop essential business skills related to commercialization. Close collaboration with fellow DCs is key to optimizing the multi-jet device for market readiness.
Career Aspirations: After completing his PhD, Pradeep aims to pursue roles in the research and development sector with a focus on EU policymaking. He hopes to combine technical innovation with regulatory expertise, advancing the medical sector in Europe and making significant contributions to the development of medical devices and treatments.
“From my master’s thesis at UGent to now as a Doctoral Candidate in PlasmACT, this journey has been an incredible learning experience. I’m excited to contribute to the development of plasma technology and bring meaningful change to the medical field.”
Institution:
GREMI Laboratory, Centre National de la Recherche Scientifique (CNRS), Université d’Orléans
Location:
Orléans, France
Research Focus:
Optimizing plasma jet interactions with biological tissues
DC4 – Ritu Zende
Ritu’s project centers on optimizing plasma jet interactions with biological tissues. Her work involves studying how different gas compositions affect plasma generation and tissue interactions. By developing in situ diagnostic tools, Ritu aims to monitor and control plasma delivery, paving the way for innovations in non-invasive medical treatments.
Key Techniques: Plasma jet device interactions
Expected Impact: Ritu’s research aims to advance plasma medicine by optimizing plasma jet devices for precise, targeted medical treatments. By characterizing reactive species and developing in situ diagnostics, this work could improve therapies for conditions like actinic keratosis, offering safer, non-invasive options.
Motivation: “The potential of plasma technology to enable precise, non-invasive therapies excites me. It’s inspiring to work on research that can transform medical treatments and significantly improve patient care.”
Fun Fact: Ritu is an adventurous spirit who loves exploring new places, trying new flavors, and diving into fascinating stories. “Every day is an adventure!”
Collaborations: As part of the PlasmACT consortium, Ritu will undertake secondments at Universitätsmedizin Rostock, focusing on plasma effects on cancer cells, and at the Institute for Implant Technology and BioMaterials (IIB), where she will develop quality control strategies and test the plasma device per 93/42/EEC standards.
Career Aspirations: Ritu dreams of becoming an independent researcher in the medical sector, leading a lab that bridges the gap between academia and industry. Her goal is to ensure that scientific discoveries translate into impactful, practical solutions for society.
“Being part of the PlasmACT network has fueled my passion for plasma research, driving me to explore its transformative potential. Collaborating with talented minds has deepened my commitment to making a real-world impact through innovation.”
Institution:
Eindhoven University of Technology
Location:
Eindhoven, The Netherlands
Research Focus:
Characterization of non-thermal atmospheric plasma jet using emission spectroscopy
DC5 – Sidharth
The main focus of Sidharth’s project is the characterization of the non-thermal atmospheric pressure plasma jet to be used by all partners in the project in view of primarily gas phase electric fields and how they are influenced by substrates.
Key Techniques: Emission Spectroscopy, Thomson Scattering, Electrical and Power measurements of plasma Jet Device, Fast Imaging
Expected Impact: The use of plasma jet treatment necessitates a thorough understanding of the electric field at the patient’s surface to ensure safety and prevent any potential harm. Sidharth’s project focuses on investigating the electric field as a critical safety parameter. Additionally, it explores the complexity of using multiple plasma jets and the interactions between their electric fields.
Motivation: “The interdisciplinary opportunities offered by plasma medicine, which combines physics, chemistry, and biology, strongly motivate me to pursue this field. The potential to make meaningful contributions to medicine, particularly in areas such as oncology, dentistry, and wound healing, further highlights the significance of this research. Additionally, the chance to work with world-class facilities, collaborate with leading researchers, and employ diverse analytical methods makes this area of study especially compelling for me.”
Fun Fact: Sidharth likes to swim and play badminton. As well as this, he is a „social being“ and loves to connect with people!
Collaborations: As a part of PlasmACT, Sidharth has ample opportunity to collaborate with peers in different institutions. This will primarily be with CNRS, University of Orleans in France, who are already in frequent contact regarding the plasma source and he’s looking forward to furthering his collaboration with them.
Career Aspirations: Sidharth aspires to build a career as a researcher, potentially advancing to a scientist role in the future. He aims to engage in collaborative projects that not only drive innovation but also contribute to the development of his home country.
“PlasmACT has given me a valuable opportunity to connect with individuals from diverse backgrounds, fostering both social interactions and professional networking that could benefit my future career. The dual focus of the doctoral network—conducting research to address real-world challenges while participating in training and workshops to collaborate with industry and translate knowledge into practical applications – is an aspect I find particularly compelling.”
Institution:
Rostock University Medical Center
Location:
Rostock, Germany
Research Focus:
Assessing the safety of plasma and its influence on DNA repair in patient-derived samples
DC6 – Agnieszka Ossowska
Agnieszka’s project centers on testing the safety and efficacy of an innovative plasma jet developed within PlasmACT. Working alongside collaborators at CNRS/GREMI, Agnieszka aims to ensure the plasma jet effectively targets actinic keratosis (AK) cells without causing harm to surrounding healthy cells. Her work spans from cell and animal models to samples donated by AK patients—leveraging an ideal clinical setting to validate the potential of this technology for real-world dermatological use.
Expected Impact: Her goal is to pave the way for plasma multi-jet technology in routine clinical settings, with a focus on preventing skin cancer by treating AK safely and effectively. If successful, Agnieszka’s research could serve as a foundation for future clinical trials and eventually integrate plasma-based solutions into standard dermato-oncology care.
Motivation: „My undergraduate studies sparked a strong interest in molecular biology and dermatology, leading me to PlasmACT. Knowing that my work could directly advance medical innovation is inspiring. I’m thrilled to bridge academia and industry within this network, gaining practical experience and making a tangible impact.“
Career Aspirations: Agnieszka aims to transition into regulatory affairs, advisory roles, or policy sectors focused on medical technology, where she can bridge scientific insights with societal impact.
Collaborations: Academic Secondment: GREMI (CNRS), Industry Partner: Cortronik GmbH
„Moving abroad was daunting, but joining the dynamic and collaborative environment at PlasmACT and University Medical Centre Rostock has been an enriching experience. I look forward to all we can achieve together!“
Institution:
University of Antwerp
Location:
Antwerp, Belgium
Research Focus:
Modeling the interaction of plasma species with biomolecules
DC7 – Mac Veldhuizen
Mac’s project focuses on understanding the effect of reactive oxygen and nitrogen species (RONS) on biological targets (e.g. proteins) using chemical modelling, as well as providing insights on the permeability of different RONS into the skin
Key Techniques: Chemical modelling (mainly non-reactive molecular dynamics but also kinetic modelling or reactive molecular dynamics).
Expected Impact: Mac’s research aims to create a fundamental understanding at the atomic level of the mechanisms of RONS. This should help other scientists to make choices to effectively use RONS for medicinal applications.
Motivation: “I have always been drawn towards understanding life at a molecular level, and I think computational tools are the best way to unravel life in detail.”
Collaborations: Mac currently works closely with CORE, the Center for Oncological Research Antwerpen, as well as undertaking a secondment at CNRS as part of the PlasmACT consortium
Career Aspirations: Mac is currently exploring future career paths and is open to opportunities in both academia and industry. Whether continuing as a post-doctoral researcher or transitioning to an industry role, Mac is eager to apply his expertise in plasma technology to contribute to impactful advancements in science and healthcare.
“I like working with cold plasma applications in the PlasmACT because it combines many fields (like medicine, chemistry, biology and physics) to work a common goal of both creating a fundamental understanding of RONS but also find actual applications.”
Institution:
University of Antwerp
Location:
Antwerp, Belgium
Research Focus:
Immunobiology of Plasma-Treated Diseased Keratinocytes
DC8 – Aminur Rashid
Aminur’s project explores the immunobiology of actinic keratosis (AK) following gas plasma treatment. By testing the GREMI multijet device, he aims to understand how plasma can induce immunogenic cell death in AK cells and potentially stimulate immune activation. Aminur is also investigating the combined effects of plasma treatment with standard AK therapies.
Expected Impact: Aminur’s work could provide critical insights into the mechanisms of gas plasma therapy, helping to establish it as a potential treatment for AK and potentially broader applications in immuno-oncology. Combining plasma with current treatments could offer a more effective, less invasive approach, paving the way for innovations in plasma medicine.
Motivation: “Plasma technology offers a minimally invasive approach with the potential to revolutionize cancer and skin disease treatment, which is incredibly exciting. Knowing my research could make a real difference in healthcare and patient outcomes keeps me motivated every day.”
Fun Fact: Originally from India, Aminur’s academic journey has taken him from Italy to Belgium, driven by his passion for science and discovery.
Career Aspirations: Aminur aspires to lead his own research group in plasma-oncology, focusing on bridging research and clinical application to bring novel therapies from the lab to patient care.
Collaborations: Collaborates with DC1 and DC2 at INP Greifswald, Germany, and DC6 at UMR, Germany. Undertaking a 6-month industrial placement at Miltenyi Biotec, Germany, to gain practical R&D experience
„From India to Italy and now Belgium, my journey as an MSCA Fellow in the PlasmACT consortium has been one of growth, discovery, and endless learning. Every step forward in my research brings me closer to unravelling the mysteries of science, and I am excited to see where this adventure takes me!“
